| http://purl.uniprot.org/citations/26856406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26856406 | http://www.w3.org/2000/01/rdf-schema#comment | "Host and parasite genotypes are among the factors associated with congenital toxoplasmosis pathogenesis. As HLA class II molecules play a key role in the immune system regulation, the aim of this study was to investigate whether HLA-DQA1/B1 alleles are associated with susceptibility or protection to congenital toxoplasmosis. One hundred and twenty-two fetuses with and 103 without toxoplasmosis were studied. The two study groups were comparable according to a number of socio-demographic and genetic variables. HLA alleles were typed by PCR-SSP. In the HLA-DQA1 region, the allele frequencies showed that *01:03 and *03:02 alleles could confer susceptibility (OR= 3.06, p = 0.0002 and OR= 9.60, p= 0.0001, respectively) as they were more frequent among infected fetuses. Regarding the HLA-DQB1 region, the *05:04 allele could confer susceptibility (OR = 6.95, p < 0.0001). Of the 122 infected fetuses, 10 presented susceptibility haplotypes contrasting with only one in the non-infected group. This difference was not statistically significant after correction for multiple comparison (OR = 9.37, p=0.011). In the casuistic, there were two severely damaged fetuses with high parasite loads determined in amniotic fluid samples and HLA-DQA1 susceptibility alleles. In the present study, a discriminatory potential of HLA-DQA1/B1 alleles to identify susceptibility to congenital toxoplasmosis and the most severe cases has been shown."xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.org/dc/terms/identifier | "doi:10.1080/21505594.2016.1150401"xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/author | "Yamamoto L."xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/author | "Okay T.S."xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/author | "Rodrigues J.C."xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/author | "Kanunfre K.A."xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/author | "Shimokawa P.T."xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/author | "Targa L.S."xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/name | "Virulence"xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/pages | "456-464"xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/title | "HLA-DQA1/B1 alleles as putative susceptibility markers in congenital toxoplasmosis."xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26856406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26856406 |
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