| http://purl.uniprot.org/citations/26868148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26868148 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent evidence has revealed that senescence induction requires fine-tuned activation of p53, however, mechanisms underlying the regulation of p53 activity during senescence have not as yet been clearly established. We demonstrate here that SCF(Fbxo22)-KDM4A is a senescence-associated E3 ligase targeting methylated p53 for degradation. We find that Fbxo22 is highly expressed in senescent cells in a p53-dependent manner, and that SCF(Fbxo22) ubiquitylated p53 and formed a complex with a lysine demethylase, KDM4A. Ectopic expression of a catalytic mutant of KDM4A stabilizes p53 and enhances p53 interaction with PHF20 in the presence of Fbxo22. SCF(Fbxo22)-KDM4A is required for the induction of p16 and senescence-associated secretory phenotypes during the late phase of senescence. Fbxo22(-/-) mice are almost half the size of Fbxo22(+/-) mice owing to the accumulation of p53. These results indicate that SCF(Fbxo22)-KDM4A is an E3 ubiquitin ligase that targets methylated p53 and regulates key senescent processes."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms10574"xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Miyamoto T."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Kitagawa M."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Takahashi S."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Nakanishi M."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Sawada Y."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Nakanishi K."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Kitagawa K."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Aburatani H."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Okabe A."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Kuno T."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Miyoshi I."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Johmura Y."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/author | "Naiki-Ito A."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/pages | "10574"xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/title | "SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence."xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26868148 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26868148 |
| http://purl.uniprot.org/citations/26868148 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26868148 |