| http://purl.uniprot.org/citations/26871477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26871477 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNA-150 (miR-150) is frequently dysregulated in cancer and is involved in carcinogenesis and cancer progression. In this study, we found that miR-150 was significantly downregulated in hepatocellular carcinoma (HCC) tissues compared to adjacent noncancerous tissues. Low levels of miR-150 were significantly associated with worse clinicopathological characteristics and a poor prognosis for patients with HCC. miR-150 overexpression inhibited cell proliferation, migration and invasion in vitro and tumor growth and metastasis in vivo. Further experiments indicated that Grb2-associated binding protein 1 (GAB1) was a direct target of miR-150 in HCC cells. In addition, GAB1 expression was increased in HCC tissues and inversely correlated with miR-150 levels. Knockdown of GAB1 mimicked the tumor-suppressive effects of miR-150 overexpression on HCC cells, whereas restoration of GAB1 expression partially abolished the inhibitory effects. Moreover, miR-150 overexpression decreased GAB1 expression, subsequently downregulated phospho-ERK1/2 and suppressed epithelial-mesenchymal-transition (EMT). These effects caused by miR-150 overexpression were alleviated by exogenous GAB1 expression. Taken together, this study demonstrates that miR-150 may be useful as a prognostic marker and that the identified miR-150-GAB1-ERK axis is a potential therapeutic target for HCC."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.7292"xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Duan J."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Ruan B."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Qu S."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Dai B."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Dou K."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Ding R."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/author | "Shang R."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/pages | "11595-11608"xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/title | "MicroRNA-150 suppresses cell proliferation and metastasis in hepatocellular carcinoma by inhibiting the GAB1-ERK axis."xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26871477 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26871477 |