| http://purl.uniprot.org/citations/26871599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26871599 | http://www.w3.org/2000/01/rdf-schema#comment | "Glioblastoma (GBM) is an aggressive brain tumor which is currently treated with temozolomide (TMZ). Tumors usually become resistant to TMZ and recur; no effective therapy is then available. Monoamine Oxidase A (MAO A) oxidizes monoamine neurotransmitters resulting in reactive oxygen species which cause cancer. This study shows that MAO A expression is increased in human glioma tissues and cell lines. MAO A inhibitors, clorgyline or the near-infrared-dye MHI-148 conjugated to clorgyline (NMI), were cytotoxic for glioma and decreased invasion in vitro. Using the intracranial TMZ-resistant glioma model, clorgyline or NMI alone or in combination with low-dose TMZ reduced tumor growth and increased animal survival. NMI was localized specifically to the tumor. Immunocytochemistry studies showed that the MAO A inhibitor reduced proliferation, microvessel density and invasion, and increased macrophage infiltration. In conclusion, we have identified MAO A inhibitors as potential novel stand-alone drugs or as combination therapy with low dose TMZ for drug-resistant gliomas. NMI can also be used as a non-invasive imaging tool. Thus has a dual function for both therapy and diagnosis."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.7283"xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Chen T.C."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Shih J.C."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Yeh T.S."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Hofman F.M."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Olenyuk B.Z."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Jhaveri N."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Kota R."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Groshen S.L."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Kushal S."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/author | "Vaikari V.P."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/pages | "13842-13853"xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/title | "Monoamine oxidase A (MAO A) inhibitors decrease glioma progression."xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26871599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26871599 |
| http://purl.uniprot.org/citations/26871599 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26871599 |
| http://purl.uniprot.org/uniprot/#_A0A1W5KJW8-mappedCitation-26871599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26871599 |
| http://purl.uniprot.org/uniprot/#_Q53EZ0-mappedCitation-26871599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26871599 |
| http://purl.uniprot.org/uniprot/#_P21397-mappedCitation-26871599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26871599 |