| http://purl.uniprot.org/citations/26873505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26873505 | http://www.w3.org/2000/01/rdf-schema#comment | "Aldose reductase (AR; gene AKR1B1) is the rate-limiting enzyme of the polyol pathway and has been associated with diabetes and atherosclerosis. Here, we sought to identify the mechanisms underlying differential AR expression in human atherosclerotic plaque macrophages. In vitro, M1-polarized human monocyte-derived macrophages expressed significantly higher levels of AKR1B1 mRNA and AR protein compared with M2-polarized macrophages. AR activity was significantly higher in M1 macrophages. AKR1B1 mRNA expression correlated positively with the M1 marker TNF(r = 0.430,P = 0.006) and negatively with the M2 marker MRC1 (r = -0.443,P = 0.044). Increased AR expression in M1 macrophages depended on hyperglycemia. Concomitantly, expression of SLC2A1 (coding for the Glc transporter GLUT-1) was significantly higher in M1 than in M2 macrophages. Pharmacological inhibition of GLUT-1 using STF-32 completely abrogated Glc-induced AR up-regulation in M1 macrophages. When analyzing AR expression in post-mortem coronary artery plaque macrophages, a history of diabetes was associated with a significantly increased proportion of CD68(+)AR(++)macrophages, supporting the in vivo relevance of our in vitro findings. We demonstrate that the phenotype of atherosclerotic plaque macrophages may be affected by cardiovascular risk factors such as hyperglycemia. Our data illustrate the complex interplay between systemic and local factors in atherogenesis."xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.org/dc/terms/identifier | "doi:10.1177/1753425916632053"xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/author | "Katus H.A."xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/author | "Rupp G."xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/author | "Gleissner C.A."xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/author | "Erbel C."xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/author | "Akhavanpoor M."xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/author | "Doesch A.O."xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/author | "Domschke G."xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/author | "Linden F."xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/name | "Innate Immun"xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/pages | "230-237"xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/title | "Differential regulation of aldose reductase expression during macrophage polarization depends on hyperglycemia."xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/26873505 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26873505 |
| http://purl.uniprot.org/citations/26873505 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26873505 |
| http://purl.uniprot.org/uniprot/#_P11166-mappedCitation-26873505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26873505 |
| http://purl.uniprot.org/uniprot/#_A0A8B0RIZ3-mappedCitation-26873505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26873505 |
| http://purl.uniprot.org/uniprot/#_A0A8B0RJV8-mappedCitation-26873505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26873505 |
| http://purl.uniprot.org/uniprot/#_B4DDR6-mappedCitation-26873505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26873505 |
| http://purl.uniprot.org/uniprot/#_B4DKW1-mappedCitation-26873505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26873505 |
| http://purl.uniprot.org/uniprot/#_B3KVN0-mappedCitation-26873505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26873505 |
| http://purl.uniprot.org/uniprot/#_O15289-mappedCitation-26873505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26873505 |