| http://purl.uniprot.org/citations/26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26876096 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal exocytosis is mediated by SNARE proteins, which assemble into a highly stable four-helical bundle in a process that is not well understood. Here, electron paramagnetic resonance spectroscopy was used to examine how the t-SNAREs syntaxin and SNAP25 assemble in the presence and absence of the regulatory protein Munc18-1. Syntaxin and SNAP25 form a 2:1 complex, which is structurally heterogeneous and persists in the presence of excess SNAP25. Munc18-1 dissociates this 2:1 complex, but a 1:1 complex is retained where syntaxin is in a closed state. In the absence of an N-terminal fragment of syntaxin, Munc18-1 also stabilizes a 1:1 complex of sytaxin/SNAP25; however, syntaxin now samples an open state. These data demonstrate that the open-closed syntaxin equilibrium is shifted toward the open state when syntaxin and Munc18-1 are associated with SNAP25, and the results indicate that a syntaxin/SNAP25:Munc18-1 complex is a likely starting point for SNARE assembly."xsd:string |
| http://purl.uniprot.org/citations/26876096 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2016.01.005"xsd:string |
| http://purl.uniprot.org/citations/26876096 | http://purl.uniprot.org/core/author | "Cafiso D.S."xsd:string |
| http://purl.uniprot.org/citations/26876096 | http://purl.uniprot.org/core/author | "Dawidowski D."xsd:string |
| http://purl.uniprot.org/citations/26876096 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26876096 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/26876096 | http://purl.uniprot.org/core/pages | "392-400"xsd:string |
| http://purl.uniprot.org/citations/26876096 | http://purl.uniprot.org/core/title | "Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex."xsd:string |
| http://purl.uniprot.org/citations/26876096 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/26876096 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26876096 |
| http://purl.uniprot.org/citations/26876096 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26876096 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K3F2-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_D4A5W9-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_P61765-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_A6JU89-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_A6JU90-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AVN2-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_A0A8L2ULG5-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_A0A1E1ERK2-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A8W2-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_A0A8I6ABE0-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_A6HQK1-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_A6HQK2-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |
| http://purl.uniprot.org/uniprot/#_A6HQK3-mappedCitation-26876096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26876096 |