| http://purl.uniprot.org/citations/26880549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26880549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26880549 | http://www.w3.org/2000/01/rdf-schema#comment | "Mouse CA1 pyramidal neurons express apamin-sensitive SK2-containing channels in the post-synaptic membrane, positioned close to NMDA-type (N-methyl-D-aspartate) glutamate receptors. Activated by synaptically evoked NMDAR-dependent Ca(2+) influx, the synaptic SK2-containing channels modulate excitatory post-synaptic responses and the induction of synaptic plasticity. In addition, their activity- and protein kinase A-dependent trafficking contributes to expression of long-term potentiation (LTP). We have identified a novel synaptic scaffold, MPP2 (membrane palmitoylated protein 2; p55), a member of the membrane-associated guanylate kinase (MAGUK) family that interacts with SK2-containing channels. MPP2 and SK2 co-immunopurified from mouse brain, and co-immunoprecipitated when they were co-expressed in HEK293 cells. MPP2 is highly expressed in the post-synaptic density of dendritic spines on CA1 pyramidal neurons. Knocking down MPP2 expression selectively abolished the SK2-containing channel contribution to synaptic responses and decreased LTP. Thus, MPP2 is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2-containing channels."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.12637"xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.12637"xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Adelman J.P."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Adelman J.P."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Lujan R."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Lujan R."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Kim G."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Kim G."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Maylie J."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Maylie J."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Fakler B."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Fakler B."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Schwenk J."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Schwenk J."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Aguado C."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Aguado C."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Kelley M.H."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/author | "Kelley M.H."xsd:string |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26880549 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |