| http://purl.uniprot.org/citations/26881015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26881015 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypochlorite-modified albumin (HOCl-alb) has been linked to endothelial dysfunction, which plays an important role in the development of hypertension, diabetes, and chronic kidney disease. However, whether HOCl-alb induces endothelial dysfunction via vascular inflammation and whether a signaling pathway is involved are unknown and have not been investigated. HOCl-alb was found to upregulate ICAM-1 expression in human umbilical vein endothelial cells (HUVECs) in a time- and dose-dependent manner. HOCl-alb time-dependently phosphorylated ERK1/2 and p38(MAPK). HOCl-alb also activated NF-κB. ICAM-1 expression was dose-dependently inhibited by U0126 (a specific inhibitor of MEK1/2, a signal upstream from ERK1/2), SB203580 (a specific inhibitor of p38(MAPK)), and SN50 (a specific inhibitor of NF-κB). U0126 and SB203580 both counteracted the activation of NF-κB, whereas the phosphorylation of ERK1/2 and p38(MAPK) was not blocked by SN50. ERK1/2 phosphorylation was blocked by U0126 but not by SB203580, and p38(MAPK) activity was reduced by SB203580 but not by U0126. Apocynin, a specific NADPH oxidase (NOX) inhibitor, inhibited ICAM-1 expression and the activity of ERK1/2, p38(MAPK), and NF-κB. These results indicate that HOCl-alb-induced ICAM-1 expression is caused by the activation of a redox-sensitive intracellular signal cascade involving ERK1/2 and p38(MAPK), culminating in the activation of NF-κB and involving NOXs among the upstream signals."xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.org/dc/terms/identifier | "doi:10.1155/2016/1852340"xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/author | "Chen Y.H."xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/author | "Liu Z.R."xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/author | "Long H.B."xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/author | "Niu H.X."xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/author | "Tang D.D."xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/author | "Peng F.F."xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/name | "Oxid Med Cell Longev"xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/pages | "1852340"xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/title | "Hypochlorite-Modified Albumin Upregulates ICAM-1 Expression via a MAPK-NF-kappaB Signaling Cascade: Protective Effects of Apocynin."xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://purl.uniprot.org/core/volume | "2016"xsd:string |
| http://purl.uniprot.org/citations/26881015 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26881015 |
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