Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/26882171http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26882171http://www.w3.org/2000/01/rdf-schema#comment"

Background and aim

Although an eight-residue insertion in HLA-DQβ1 has been recently identified as a genetic risk factor for idiopathic achalasia, other risk factors are still unknown. In the present study, we carried out an epidemiological survey and a genotype-phenotype (G×P) analysis to gain further insights into the etiology of achalasia.

Methods

We obtained medical data from 696 achalasia patients and 410 controls, as well as their first-degree relatives (2543 of patients and 1497 of controls). For the G×P analysis, we stratified the patients into HLA-DQβ1 insertion carriers and noncarriers.

Results

Our data show that patients are more often affected by viral infections before achalasia onset (P<0.0001, most significantly for varicella zoster virus infections). In addition, allergic (P=0.0005) and autoimmune disorders (P=0.0007, most significantly for psoriasis and Sjögren's syndrome) represent comorbid disease conditions. First-degree relatives of patients also show higher prevalence rates of allergic disorders (P=0.0007) and psoriasis (P=0.016) compared with control relatives. Moreover, the G×P analysis reveals that achalasia is triggered by pregnancies in female HLA-DQβ1 insertion carriers (P=0.031).

Conclusion

Our data point to a role of viral infections in the development of achalasia. In addition, they provide evidence for a relationship between achalasia and allergic, as well as autoimmune, disorders. Furthermore, pregnancy seems to be a disease-triggering factor in female HLA-DQβ1 insertion carriers, which points to hormonal and/or immunosuppressive factors influencing disease development."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.org/dc/terms/identifier"doi:10.1097/meg.0000000000000602"xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Lehmann G."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Muller M."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Lang H."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Nothen M.M."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Fimmers R."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Knapp M."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Wouters M.M."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Schumacher J."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Becker J."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Eckardt A.J."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Hess T."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Lingohr P."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Vieth M."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Gockel H.R."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Boeckxstaens G.E."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Gockel I."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"von Rahden B.H."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Venerito M."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Seewald S."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Matthaei H."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Veits L."xsd:string
http://purl.uniprot.org/citations/26882171http://purl.uniprot.org/core/author"Huneburg R."xsd:string
▶