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http://purl.uniprot.org/citations/26884181http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26884181http://www.w3.org/2000/01/rdf-schema#comment"Programmed cell death (PCD) is usually considered a cell-autonomous suicide program, synonymous with apoptosis. Recent research has revealed that PCD is complex, with at least a dozen cell death modalities. Here, we demonstrate that the large-scale nonapoptotic developmental PCD in the Drosophila ovary occurs by an alternative cell death program where the surrounding follicle cells nonautonomously promote death of the germ line. The phagocytic machinery of the follicle cells, including Draper, cell death abnormality (Ced)-12, and c-Jun N-terminal kinase (JNK), is essential for the death and removal of germ-line-derived nurse cells during late oogenesis. Cell death events including acidification, nuclear envelope permeabilization, and DNA fragmentation of the nurse cells are impaired when phagocytosis is inhibited. Moreover, elimination of a small subset of follicle cells prevents nurse cell death and cytoplasmic dumping. Developmental PCD in the Drosophila ovary is an intriguing example of nonapoptotic, nonautonomous PCD, providing insight on the diversity of cell death mechanisms."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.org/dc/terms/identifier"doi:10.1073/pnas.1522830113"xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/author"Taylor J.D."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/author"McCall K."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/author"Etchegaray J.I."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/author"Meehan T.L."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/author"Timmons A.K."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/author"Mondragon A.A."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/author"Moynihan K.E."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/author"Schenkel C.E."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/author"Yalonetskaya A."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/pages"E1246-55"xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/title"Phagocytosis genes nonautonomously promote developmental cell death in the Drosophila ovary."xsd:string
http://purl.uniprot.org/citations/26884181http://purl.uniprot.org/core/volume"113"xsd:string
http://purl.uniprot.org/citations/26884181http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26884181
http://purl.uniprot.org/citations/26884181http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26884181
http://purl.uniprot.org/uniprot/#_A0A0B4KI69-mappedCitation-26884181http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884181
http://purl.uniprot.org/uniprot/#_E1JHD6-mappedCitation-26884181http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884181
http://purl.uniprot.org/uniprot/#_A0A0B4KEI6-mappedCitation-26884181http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884181
http://purl.uniprot.org/uniprot/#_A0A0B4LHU8-mappedCitation-26884181http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884181
http://purl.uniprot.org/uniprot/#_A0A0B4LHX7-mappedCitation-26884181http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884181
http://purl.uniprot.org/uniprot/#_A0A0B4K7Q6-mappedCitation-26884181http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884181