Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26884287http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Latent autoimmune diabetes in adults (LADA) is a slow-developing form of autoimmune diabetes, characterised by the presence of type 1 diabetes-associated autoantibody and presentation at diagnosis similar to patients with type 2 diabetes. The aim of this study was to determine the prevalence of auto-antibodies related to endocrine autoimmune diseases in patients with LADA and to assess their association with HLA genotype.

Material and methods

We evaluated the presence of anti-thyroglobulin (ATG), anti-thyroid peroxidase (ATPO), anti-tissue transglutaminase IgA (ATTA), and anti 21 hydroxylase (A21H) in 70 patients with LADA, 69 with Type 2 diabetes, and in 50 healthy controls HLA genotype was assed in subpopulation of sluclied subjects.

Results

The presence of ATPO (28.6 vs. 10%); ATG (28.6 vs. 14%) was higher in patients with LADA in comparison to healthy controls and ATPO in comparison to patients with type 2 diabetes (38.6 vs. 17.4 %). In patients with LADA the presence of autoimmune thyroid autoantibodies was associated with newly diagnosed subclinical hypothyroidism; almost 7% of patients presented with high TSH. The presence of A21H (2.86 vs. 5.8 vs. 6.1%) and ATTA (2.86 vs. 4.3 vs. 6.0%) was not different between groups. Patients with high TSH level were positive for DQA1*0301 and DRB1*04 HLA genotype: DQB1*0201 and DQB1*02 were higher in patients positive for ATTA.

Conclusions

Patients with LADA have higher prevalence of thyroid autoimmune diseases. In patients with LADA similarly to type 1 genotype DQA1*0301 seems to CONFER susceptibility to thyroid autoimmunity, and DQB1*0201 to celiac disease."xsd:string
http://purl.uniprot.org/citations/26884287http://purl.org/dc/terms/identifier"doi:10.5603/ep.a2016.0017"xsd:string
http://purl.uniprot.org/citations/26884287http://purl.uniprot.org/core/author"Gorska M."xsd:string
http://purl.uniprot.org/citations/26884287http://purl.uniprot.org/core/author"Kretowski A."xsd:string
http://purl.uniprot.org/citations/26884287http://purl.uniprot.org/core/author"Szelachowska M."xsd:string
http://purl.uniprot.org/citations/26884287http://purl.uniprot.org/core/author"Wawrusiewicz-Kurylonek N."xsd:string
http://purl.uniprot.org/citations/26884287http://purl.uniprot.org/core/author"Szepietowska B."xsd:string
http://purl.uniprot.org/citations/26884287http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26884287http://purl.uniprot.org/core/name"Endokrynol Pol"xsd:string
http://purl.uniprot.org/citations/26884287http://purl.uniprot.org/core/pages"197-201"xsd:string
http://purl.uniprot.org/citations/26884287http://purl.uniprot.org/core/title"Endocrine autoimmunity in patients with Latent Autoimmune Diabetes in Adults (LADA) - association with HLA genotype."xsd:string
http://purl.uniprot.org/citations/26884287http://purl.uniprot.org/core/volume"67"xsd:string
http://purl.uniprot.org/citations/26884287http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26884287
http://purl.uniprot.org/citations/26884287http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26884287
http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884287
http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884287
http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884287
http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884287
http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884287
http://purl.uniprot.org/uniprot/#_A0A0A7CAC7-mappedCitation-26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884287
http://purl.uniprot.org/uniprot/#_A0A0A7CAE0-mappedCitation-26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884287
http://purl.uniprot.org/uniprot/#_A0A0A7CAE6-mappedCitation-26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884287
http://purl.uniprot.org/uniprot/#_A0A0E3DCZ4-mappedCitation-26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884287
http://purl.uniprot.org/uniprot/#_A0A0E3DCZ9-mappedCitation-26884287http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26884287
▶