| http://purl.uniprot.org/citations/26888216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26888216 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone acetylation plays a pivotal role in transcriptional regulation, and ATP-dependent nucleosome remodeling activity is required for optimal transcription from chromatin. While these two activities have been well characterized, how they are coordinated remains to be determined. We discovered ATP-dependent histone H2A acetylation activity in Drosophila nuclear extracts. This activity was column purified and demonstrated to be composed of the enzymatic activities of CREB-binding protein (CBP) and SMARCAD1, which belongs to the Etl1 subfamily of the Snf2 family of helicase-related proteins. SMARCAD1 enhanced acetylation by CBP of H2A K5 and K8 in nucleosomes in an ATP-dependent fashion. Expression array analysis of S2 cells having ectopically expressed SMARCAD1 revealed up-regulated genes. Using native genome templates of these up-regulated genes, we found that SMARCAD1 activates their transcription in vitro. Knockdown analysis of SMARCAD1 and CBP indicated overlapping gene control, and ChIP-seq analysis of these commonly controlled genes showed that CBP is recruited to the promoter prior to SMARCAD1. Moreover, Drosophila genetic experiments demonstrated interaction between SMARCAD1/Etl1 and CBP/nej during development. The interplay between the remodeling activity of SMARCAD1 and histone acetylation by CBP sheds light on the function of chromatin and the genome-integrity network."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep20179"xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Kubota K."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Fujii S."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Ito T."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Nakagawa T."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Yamashita S."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Yoneda M."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Ikura T."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Ueda H."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Imamura Y."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Higashi M."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Kraus W.L."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Iida M."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Asahara H."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Nandu T."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/author | "Doiguchi M."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/pages | "20179"xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/title | "SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation."xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26888216 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26888216 |