| http://purl.uniprot.org/citations/26894530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26894530 | http://www.w3.org/2000/01/rdf-schema#comment | "D-Alanyl-D-alanine is an essential precursor of bacterial peptidoglycan and is synthesized by D-alanine-D-alanine ligase (DDL) with hydrolysis of ATP; this reaction makes DDL an important drug target for the development of antibacterial agents. Five crystal structures of DDL from Yersinia pestis (YpDDL) were determined at 1.7-2.5 Å resolution: apo, AMP-bound, ADP-bound, adenosine 5'-(β,γ-imido)triphosphate-bound, and D-alanyl-D-alanine- and ADP-bound structures. YpDDL consists of three domains, in which four loops, loop 1, loop 2 (the serine loop), loop 3 (the ω-loop) and loop 4, constitute the binding sites for two D-alanine molecules and one ATP molecule. Some of them, especially the serine loop and the ω-loop, show flexible conformations, and the serine loop is mainly responsible for the conformational change in substrate nucleotide phosphates. Enzyme-kinetics assays were carried out for both the D-alanine and ATP substrates and a substrate-binding mechanism was proposed for YpDDL involving conformational changes of the loops."xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.org/dc/terms/identifier | "doi:10.1107/s2059798315021671"xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/author | "Tran H.T."xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/author | "Kang L.W."xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/author | "Ahn Y.J."xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/author | "Ngo H.P."xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/author | "Huynh K.H."xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/author | "Hong M.K."xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/name | "Acta Crystallogr D Struct Biol"xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/pages | "12-21"xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/title | "Structure of D-alanine-D-alanine ligase from Yersinia pestis: nucleotide phosphate recognition by the serine loop."xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/26894530 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26894530 |
| http://purl.uniprot.org/citations/26894530 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26894530 |
| http://purl.uniprot.org/uniprot/#_Q8ZIE7-mappedCitation-26894530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26894530 |
| http://purl.uniprot.org/uniprot/Q8ZIE7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26894530 |