| http://purl.uniprot.org/citations/26900751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26900751 | http://www.w3.org/2000/01/rdf-schema#comment | "Receptor-interacting protein kinase 3 (RIPK3) functions as a key regulator of necroptosis. Here, we report that the RIPK3 expression level is negatively regulated by CHIP (carboxyl terminus of Hsp70-interacting protein; also known as STUB1) E3 ligase-mediated ubiquitylation. Chip(-/-) mouse embryonic fibroblasts and CHIP-depleted L929 and HT-29 cells exhibited higher levels of RIPK3 expression, resulting in increased sensitivity to necroptosis induced by TNF (also known as TNFα). These phenomena are due to the CHIP-mediated ubiquitylation of RIPK3, which leads to its lysosomal degradation. Interestingly, RIPK1 expression is also negatively regulated by CHIP-mediated ubiquitylation, validating the major role of CHIP in necrosome formation and sensitivity to TNF-mediated necroptosis. Chip(-/-) mice (C57BL/6) exhibit inflammation in the thymus and massive cell death and disintegration in the small intestinal tract, and die within a few weeks after birth. These phenotypes are rescued by crossing with Ripk3(-/-) mice. These results imply that CHIP is a bona fide negative regulator of the RIPK1-RIPK3 necrosome formation leading to desensitization of TNF-mediated necroptosis."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3314"xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Lee H.K."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Shin J."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Seo J."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Han S.Y."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Jeong M."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Seong J.K."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Lee E.W."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Dondelinger Y."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Seong D."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/author | "Sung H."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/pages | "291-302"xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/title | "CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3."xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/26900751 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26900751 |
| http://purl.uniprot.org/citations/26900751 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26900751 |
| http://purl.uniprot.org/uniprot/#_E9PZP3-mappedCitation-26900751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26900751 |