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http://purl.uniprot.org/citations/26902715http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26902715http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

To investigate the expression of nucleotide-binding oligomerization domain-like receptors (NLRs) in human corneas with disease and corneal cells.

Methods

The expression of NOD1, NOD2, NLRP1, and NLRP3 was analyzed using real-time RT-PCR in (1) corneas with active infection, history of herpetic stromal keratitis (HSK), chronic allograft rejection, and limbal stem cell deficiency (LSCD), and (2) human corneal cells after lipopolysaccharide (LPS) stimulation. Healthy corneas and cells without LPS served as controls.

Results

The mRNA levels of NOD2 and NLRP3 were increased in corneas with infection and HSK. Conversely, the levels of NOD1, NOD2, NLRP1, and NLRP3 transcripts were decreased in corneas with LSCD. In corneas with rejection, the expression of NOD1 and NLRP1 was downregulated. Corneal endothelial cells upregulated the expression of NOD2 and NLRP3 upon LPS.

Conclusions

The changes in the NLR expression may reflect different susceptibility to infectious and non-infectious injuries in corneas with various diseases."xsd:string
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http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/author"Lee H.J."xsd:string
http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/author"Ko J.H."xsd:string
http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/author"Ryu J.S."xsd:string
http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/author"Kim M.K."xsd:string
http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/author"Oh J.Y."xsd:string
http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/author"Wee W.R."xsd:string
http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/name"Ocul Immunol Inflamm"xsd:string
http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/pages"364-369"xsd:string
http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/title"Transcription Profiling of NOD-like Receptors in the Human Cornea with Disease."xsd:string
http://purl.uniprot.org/citations/26902715http://purl.uniprot.org/core/volume"25"xsd:string
http://purl.uniprot.org/citations/26902715http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26902715
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