| http://purl.uniprot.org/citations/26904939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26904939 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses. We mapped an Nf1-Stat3-Arid1b/β-catenin pathway that becomes active in the context of Nf1 loss. Genetic deletion of Stat3 in Schwann cell progenitors (SCPs) and Schwann cells (SCs) prevents neurofibroma formation, decreasing SCP self-renewal and β-catenin activity. β-catenin expression rescues effects of Stat3 loss in SCPs. Importantly, P-STAT3 and β-catenin expression correlate in human neurofibromas. Mechanistically, P-Stat3 represses Gsk3β and the SWI/SNF gene Arid1b to increase β-catenin. Knockdown of Arid1b or Gsk3β in Stat3(fl/fl);Nf1(fl/fl);DhhCre SCPs rescues neurofibroma formation after in vivo transplantation. Stat3 represses Arid1b through histone modification in a Brg1-dependent manner, indicating that epigenetic modification plays a role in early tumorigenesis. Our data map a neural tumorigenesis pathway and support testing JAK/STAT and Wnt/β-catenin pathway inhibitors in neurofibroma therapeutic trials."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.01.074"xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Fan D."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Huang G."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Largaespada D.A."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Zou Y."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Kim M.O."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Levy D.E."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Silverstein K.A."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Patmore D.M."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Keng V.W."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Fuchs J.R."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Ratner N."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Stemmer-Rachamimov A.O."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Jessen W.J."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Cancelas J.A."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Patel A.V."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Spinner R.J."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Schwartz E.B."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Dombi E."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Jousma E."xsd:string |
| http://purl.uniprot.org/citations/26904939 | http://purl.uniprot.org/core/author | "Tschida B.R."xsd:string |