| http://purl.uniprot.org/citations/26904954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26904954 | http://www.w3.org/2000/01/rdf-schema#comment | "Activating K-Ras mutations occurs frequently in pancreatic cancers and is implicated in their development. Cancer-initiating events, such as oncogenic Ras activation, lead to the induction of cellular senescence, a tumor suppressor response. During senescence, the decreased levels of KDM4A lysine demethylase contribute to p53 activation, however, the mechanism by which KDM4A is downregulated is unknown. We show that miR-137 targets KDM4A mRNA during Ras-induced senescence and activates both p53 and retinoblastoma (pRb) tumor suppressor pathways. Restoring the KDM4A expression contributed to bypass of miR-137-induced senescence and inhibition of endogenous miR-137 with an miRNA sponge-compromised Ras-induced senescence. miR-137 levels are significantly reduced in human pancreatic tumors, consistent with previous studies revealing a defective senescence response in this cancer type. Restoration of miR-137 expression inhibited proliferation and promoted senescence of pancreatic cancer cells. These results suggest that modulating levels of miR-137 may be important for triggering tumor suppressor networks in pancreatic cancer."xsd:string |
| http://purl.uniprot.org/citations/26904954 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.01.068"xsd:string |
| http://purl.uniprot.org/citations/26904954 | http://purl.uniprot.org/core/author | "Richard S."xsd:string |
| http://purl.uniprot.org/citations/26904954 | http://purl.uniprot.org/core/author | "Mallette F.A."xsd:string |
| http://purl.uniprot.org/citations/26904954 | http://purl.uniprot.org/core/author | "Neault M."xsd:string |
| http://purl.uniprot.org/citations/26904954 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26904954 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/26904954 | http://purl.uniprot.org/core/pages | "1966-1978"xsd:string |
| http://purl.uniprot.org/citations/26904954 | http://purl.uniprot.org/core/title | "miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells."xsd:string |
| http://purl.uniprot.org/citations/26904954 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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