| http://purl.uniprot.org/citations/26906715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26906715 | http://www.w3.org/2000/01/rdf-schema#comment | "Aurora B activation is triggered at the mitotic entry and required for proper microtubule-kinetochore attachment at mitotic phase. Therefore, Aurora B should be in inactive form in interphase to prevent aberrant cell cycle progression. However, it is unclear how the inactivation of Aurora B is sustained during interphase. In this study, we find that IK depletion-induced mitotic arrest leads to G2 arrest by Aurora B inhibition, indicating that IK depletion enhances Aurora B activation before mitotic entry. IK binds to Aurora B, and colocalizes on the nuclear foci during interphase. Our data further show that IK inhibits Aurora B activation through recruiting PP2A into IK and Aurora B complex. It is thus believed that IK, as a scaffold protein, guides PP2A into Aurora B to suppress its activity in interphase until mitotic entry."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-016-2162-9"xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Han S."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Lee M.S."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Park J.H."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Lim J.S."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Park J.S."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Jang C.Y."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Kim K.I."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/author | "Jeong A.L."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/pages | "3375-3386"xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/title | "IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells."xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/26906715 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26906715 |
| http://purl.uniprot.org/citations/26906715 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26906715 |
| http://purl.uniprot.org/uniprot/#_B2R5Y4-mappedCitation-26906715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26906715 |
| http://purl.uniprot.org/uniprot/#_B4DEH2-mappedCitation-26906715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26906715 |
| http://purl.uniprot.org/uniprot/#_Q13123-mappedCitation-26906715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26906715 |
| http://purl.uniprot.org/uniprot/#_Q9H4P6-mappedCitation-26906715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26906715 |