| http://purl.uniprot.org/citations/26908625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26908625 | http://www.w3.org/2000/01/rdf-schema#comment | "N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a strong predictor of mortality in coronary artery disease and is widely employed as a prognostic biomarker. However, a causal relationship between NT-proBNP and clinical endpoints has not been established. We have performed a genome-wide association and Mendelian randomization study of NT-proBNP. We used a discovery set of 3740 patients from the PLATelet inhibition and patient Outcomes (PLATO) trial, which enrolled 18 624 patients with acute coronary syndrome (ACS). A further set of 5492 patients, from the same trial, was used for replication. Genetic variants at two novel loci (SLC39A8 and POC1B/GALNT4) were associated with NT-proBNP levels and replicated together with the previously known NPPB locus. The most significant SNP (rs198389, pooled P = 1.07 × 10(-15)) in NPPB interrupts an E-box consensus motif in the gene promoter. The association in SLC39A8 is driven by a deleterious variant (rs13107325, pooled P = 5.99 × 10(-10)), whereas the most significant SNP in POC1B/GALNT4 (rs11105306, pooled P = 1.02 × 10(-16)) is intronic. The SLC39A8 SNP was associated with higher risk of cardiovascular (CV) death (HR = 1.39, 95% CI: 1.08-1.79, P = 0.0095), but the other loci were not associated with clinical endpoints. We have identified two novel loci to be associated with NT-proBNP in patients with ACS. Only the SLC39A8 variant, but not the NPPB variant, was associated with a clinical endpoint. Due to pleotropic effects of SLC39A8, these results do not suggest that NT-proBNP levels have a direct effect on mortality in ACS patients. PLATO Clinical Trial Registration: www.clinicaltrials.gov; NCT00391872."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddw012"xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Johansson A."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "James S."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Katus H.A."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Lindholm D."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Syvanen A.C."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Siegbahn A."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Axelsson T."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Steg P.G."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Barratt B.J."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Becker R.C."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Eriksson N."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Storey R.F."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Wallentin L."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Himmelmann A."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/author | "Varenhorst C."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/pages | "1447-1456"xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/title | "Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome."xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/26908625 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26908625 |
| http://purl.uniprot.org/citations/26908625 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26908625 |