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http://purl.uniprot.org/citations/26911435http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26911435http://www.w3.org/2000/01/rdf-schema#comment"Genome-wide association studies have identified rare variants of the gene that encodes triggering receptor expressed on myeloid cells 2 (TREM2) - an immune receptor that is found in brain microglia - as risk factors for non-familial Alzheimer disease (AD). Furthermore, animal studies have indicated that microglia have an important role in the brain response to amyloid-β (Aβ) plaques and that TREM2 variants may have an impact on such a function. We discuss how TREM2 may control the microglial response to Aβ and its impact on microglial senescence, as well as the interaction of TREM2 with other molecules that are encoded by gene variants associated with AD and the hypothetical consequences of the cleavage of TREM2 from the cell surface."xsd:string
http://purl.uniprot.org/citations/26911435http://purl.org/dc/terms/identifier"doi:10.1038/nrn.2016.7"xsd:string
http://purl.uniprot.org/citations/26911435http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/26911435http://purl.uniprot.org/core/author"Colonna M."xsd:string
http://purl.uniprot.org/citations/26911435http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26911435http://purl.uniprot.org/core/name"Nat Rev Neurosci"xsd:string
http://purl.uniprot.org/citations/26911435http://purl.uniprot.org/core/pages"201-207"xsd:string
http://purl.uniprot.org/citations/26911435http://purl.uniprot.org/core/title"TREM2 variants: new keys to decipher Alzheimer disease pathogenesis."xsd:string
http://purl.uniprot.org/citations/26911435http://purl.uniprot.org/core/volume"17"xsd:string
http://purl.uniprot.org/citations/26911435http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26911435
http://purl.uniprot.org/citations/26911435http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26911435
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http://purl.uniprot.org/uniprot/#_Q9NZC2-mappedCitation-26911435http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26911435
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