| http://purl.uniprot.org/citations/26912723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26912723 | http://www.w3.org/2000/01/rdf-schema#comment | "The initiation of eukaryotic DNA replication requires the assembly of active CMG (Cdc45-MCM-GINS) helicases at replication origins by a set of conserved and essential firing factors. This process is controlled during the cell cycle by cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK), and in response to DNA damage by the checkpoint kinase Rad53/Chk1. Here we show that Sld3, previously shown to be an essential CDK and Rad53 substrate, is recruited to the inactive MCM double hexamer in a DDK-dependent manner. Sld3 binds specifically to DDK-phosphorylated peptides from two MCM subunits (Mcm4, 6) and then recruits Cdc45. MCM mutants that cannot bind Sld3 or Sld3 mutants that cannot bind phospho-MCM or Cdc45 do not support replication. Moreover, phosphomimicking mutants in Mcm4 and Mcm6 bind Sld3 without DDK and facilitate DDK-independent replication. Thus, Sld3 is an essential "reader" of DDK phosphorylation, integrating signals from three distinct protein kinase pathways to coordinate DNA replication during S phase."xsd:string |
| http://purl.uniprot.org/citations/26912723 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201593552"xsd:string |
| http://purl.uniprot.org/citations/26912723 | http://purl.uniprot.org/core/author | "Yeeles J.T."xsd:string |
| http://purl.uniprot.org/citations/26912723 | http://purl.uniprot.org/core/author | "Diffley J.F."xsd:string |
| http://purl.uniprot.org/citations/26912723 | http://purl.uniprot.org/core/author | "Deegan T.D."xsd:string |
| http://purl.uniprot.org/citations/26912723 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26912723 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/26912723 | http://purl.uniprot.org/core/pages | "961-973"xsd:string |
| http://purl.uniprot.org/citations/26912723 | http://purl.uniprot.org/core/title | "Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation."xsd:string |
| http://purl.uniprot.org/citations/26912723 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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| http://purl.uniprot.org/uniprot/P38132#attribution-CD28EEFCDE6DA9C19DA833CB53D58914 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26912723 |
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