| http://purl.uniprot.org/citations/26916822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26916822 | http://www.w3.org/2000/01/rdf-schema#comment | "Defective primary cilia are causative to a wide spectrum of human genetic disorders, termed ciliopathies. Although the regulation of ciliogenesis is intensively studied, how it is initiated remains unclear. Here we show that type Iγ phosphatidylinositol 4-phosphate (PtdIns(4)P) 5-kinase (PIPKIγ) and inositol polyphosphate-5-phosphatase E (INPP5E), a Joubert syndrome protein, localize to the centrosome and coordinate the initiation of ciliogenesis. PIPKIγ counteracts INPP5E in regulating tau-tubulin kinase-2 (TTBK2) recruitment to the basal body, which promotes the removal of microtubule capping protein CP110 and the subsequent axoneme elongation. Interestingly, INPP5E and its product--PtdIns(4)P--accumulate at the centrosome/basal body in non-ciliated, but not ciliated, cells. PtdIns(4)P binding to TTBK2 and the distal appendage protein CEP164 compromises the TTBK2-CEP164 interaction and inhibits the recruitment of TTBK2. Our results reveal that PtdIns(4)P homoeostasis, coordinated by PIPKIγ and INPP5E at the centrosome/ciliary base, is vital for ciliogenesis by regulating the CEP164-dependent recruitment of TTBK2."xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms10777"xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/author | "Hu J."xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/author | "Wei Q."xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/author | "Ling K."xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/pages | "10777"xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/title | "Phosphatidylinositol phosphate kinase PIPKIgamma and phosphatase INPP5E coordinate initiation of ciliogenesis."xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26916822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26916822 |
| http://purl.uniprot.org/citations/26916822 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26916822 |
| http://purl.uniprot.org/uniprot/#_E0CYP4-mappedCitation-26916822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26916822 |
| http://purl.uniprot.org/uniprot/#_E0CZ71-mappedCitation-26916822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26916822 |
| http://purl.uniprot.org/uniprot/#_F7C0X9-mappedCitation-26916822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26916822 |
| http://purl.uniprot.org/uniprot/#_A2AIX0-mappedCitation-26916822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26916822 |
| http://purl.uniprot.org/uniprot/#_B4DVZ9-mappedCitation-26916822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26916822 |
| http://purl.uniprot.org/uniprot/#_F6SMP3-mappedCitation-26916822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26916822 |
| http://purl.uniprot.org/uniprot/#_F6TL71-mappedCitation-26916822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26916822 |
| http://purl.uniprot.org/uniprot/#_F6X9A4-mappedCitation-26916822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26916822 |
| http://purl.uniprot.org/uniprot/#_F6XC48-mappedCitation-26916822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26916822 |