| http://purl.uniprot.org/citations/26919467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26919467 | http://www.w3.org/2000/01/rdf-schema#comment | "The genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their similar functions and chromosomal positions. We examined variants in all functional HLA-DR beta genes in RA and SLE patients and controls, down to the amino-acid level, to better understand disease association with the HLA-DR locus. To this end, we improved an existing HLA reference panel to impute variants in all protein-coding HLA-DR beta genes. Using the reference panel, HLA variants were inferred from high-density SNP data of 9,271 RA-control subjects and 5,342 SLE-control subjects. Disease association tests were performed by logistic regression and log-likelihood ratio tests. After imputation using the newly constructed HLA reference panel and statistical analysis, we observed that HLA-DRB1 variants better accounted for the association between MHC and susceptibility to RA and SLE than did the other three HLA-DRB variants. Moreover, there were no secondary effects in HLA-DRB3, HLA-DRB4, or HLA-DRB5 in RA or SLE. Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0150283"xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Lee S.S."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Lee H.S."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Nath S.K."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Cho S.K."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Chung W.T."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Kim T.H."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Sung Y.K."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Choe J.Y."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Bang S.Y."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Bae S.C."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Kang Y.M."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Yoo D.H."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Jun J.B."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Shim S.C."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Suh C.H."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/author | "Choi C.B."xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26919467 | http://purl.uniprot.org/core/pages | "e0150283"xsd:string |