| http://purl.uniprot.org/citations/26920761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26920761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26920761 | http://www.w3.org/2000/01/rdf-schema#comment | "In Toxoplasma gondii, an intracellular parasite of humans and other animals, host mitochondrial association (HMA) is driven by a gene family that encodes multiple mitochondrial association factor 1 (MAF1) proteins. However, the importance of MAF1 gene duplication in the evolution of HMA is not understood, nor is the impact of HMA on parasite biology. Here we used within- and between-species comparative analysis to determine that the MAF1 locus is duplicated in T. gondii and its nearest extant relative Hammondia hammondi, but not another close relative, Neospora caninum Using cross-species complementation, we determined that the MAF1 locus harbors multiple distinct paralogs that differ in their ability to mediate HMA, and that only T. gondii and H. hammondi harbor HMA(+) paralogs. Additionally, we found that exogenous expression of an HMA(+) paralog in T. gondii strains that do not normally exhibit HMA provides a competitive advantage over their wild-type counterparts during a mouse infection. These data indicate that HMA likely evolved by neofunctionalization of a duplicate MAF1 copy in the common ancestor of T. gondii and H. hammondi, and that the neofunctionalized gene duplicate is selectively advantageous."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.115.186270"xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.115.186270"xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Boulanger M.J."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Boulanger M.J."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Dubey J.P."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Dubey J.P."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Parker M.L."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Parker M.L."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Adomako-Ankomah Y."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Adomako-Ankomah Y."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Boyle J.P."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Boyle J.P."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Danielson J.J."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Danielson J.J."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "English E.D."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "English E.D."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Pernas L.F."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/author | "Pernas L.F."xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/26920761 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |