| http://purl.uniprot.org/citations/26926603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26926603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26926603 | http://www.w3.org/2000/01/rdf-schema#comment | "Hair cells tightly control the dimensions of their stereocilia, which are actin-rich protrusions with graded heights that mediate mechanotransduction in the inner ear. Two members of the myosin-III family, MYO3A and MYO3B, are thought to regulate stereocilia length by transporting cargos that control actin polymerization at stereocilia tips. We show that eliminating espin-1 (ESPN-1), an isoform of ESPN and a myosin-III cargo, dramatically alters the slope of the stereocilia staircase in a subset of hair cells. Furthermore, we show that espin-like (ESPNL), primarily present in developing stereocilia, is also a myosin-III cargo and is essential for normal hearing. ESPN-1 and ESPNL each bind MYO3A and MYO3B, but differentially influence how the two motors function. Consequently, functional properties of different motor-cargo combinations differentially affect molecular transport and the length of actin protrusions. This mechanism is used by hair cells to establish the required range of stereocilia lengths within a single cell."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms10833"xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms10833"xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Dong L."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Dong L."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Choi D."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Choi D."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Ballesteros A."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Ballesteros A."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Cui R."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Cui R."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Barr-Gillespie P.G."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Barr-Gillespie P.G."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Grati M."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Grati M."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Kachar B."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Kachar B."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Krey J.F."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Krey J.F."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Jones S.M."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Jones S.M."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Millis B.A."xsd:string |
| http://purl.uniprot.org/citations/26926603 | http://purl.uniprot.org/core/author | "Millis B.A."xsd:string |