| http://purl.uniprot.org/citations/26926995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26926995 | http://www.w3.org/2000/01/rdf-schema#comment | "Although its involvement in prion replication and neurotoxicity during transmissible spongiform encephalopathies is undisputed, the physiological role of the cellular prion protein (PrP(C)) remains enigmatic. A plethora of functions have been ascribed to PrP(C) based on phenotypes of Prnp(-/-) mice. However, all currently available Prnp(-/-) lines were generated in embryonic stem cells from the 129 strain of the laboratory mouse and mostly crossed to non-129 strains. Therefore, Prnp-linked loci polymorphic between 129 and the backcrossing strain resulted in systematic genetic confounders and led to erroneous conclusions. We used TALEN-mediated genome editing in fertilized mouse oocytes to create the Zurich-3 (ZH3) Prnp-ablated allele on a pure C57BL/6J genetic background. Genomic, transcriptional, and phenotypic characterization of Prnp(ZH3/ZH3) mice failed to identify phenotypes previously described in non-co-isogenic Prnp(-/-) mice. However, aged Prnp(ZH3/ZH3) mice developed a chronic demyelinating peripheral neuropathy, confirming the crucial involvement of PrP(C) in peripheral myelin maintenance. This new line represents a rigorous genetic resource for studying the role of PrP(C) in physiology and disease."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20151610"xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/author | "Hermann M."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/author | "Aguzzi A."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/author | "Nuvolone M."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/author | "Pelczar P."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/author | "Russo G."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/author | "Sanoudou D."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/author | "Schwarz P."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/author | "Tiberi C."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/author | "Sorce S."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/author | "Minikel E."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/pages | "313-327"xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/title | "Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science."xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://purl.uniprot.org/core/volume | "213"xsd:string |
| http://purl.uniprot.org/citations/26926995 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26926995 |
| http://purl.uniprot.org/citations/26926995 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26926995 |
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| http://purl.uniprot.org/uniprot/#_P04925-mappedCitation-26926995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26926995 |
| http://purl.uniprot.org/uniprot/#_Q3UBH0-mappedCitation-26926995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26926995 |
| http://purl.uniprot.org/uniprot/#_Q4FJQ7-mappedCitation-26926995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26926995 |