| http://purl.uniprot.org/citations/26928804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26928804 | http://www.w3.org/2000/01/rdf-schema#comment | "6β-Hydroxytestosterone, a cytochrome P450 1B1-derived metabolite of testosterone, contributes to the development of angiotensin II-induced hypertension and associated cardiovascular pathophysiology. In view of the critical role of angiotensin II in the maintenance of renal homeostasis, development of hypertension, and end-organ damage, this study was conducted to determine the contribution of 6β-hydroxytestosterone to angiotensin II actions on water consumption and renal function in male Cyp1b1(+/+) and Cyp1b1(-/-) mice. Castration of Cyp1b1(+/+) mice or Cyp1b1(-/-) gene disruption minimized the angiotensin II-induced increase in water consumption, urine output, proteinuria, and sodium excretion and decreases in urine osmolality. 6β-Hydroxytestosterone did not alter angiotensin II-induced increases in water intake, urine output, proteinuria, and sodium excretion or decreases in osmolality in Cyp1b1(+/+) mice, but restored these effects of angiotensin II in Cyp1b1(-/-) or castrated Cyp1b1(+/+) mice. Cyp1b1 gene disruption or castration prevented angiotensin II-induced renal fibrosis, oxidative stress, inflammation, urinary excretion of angiotensinogen, expression of angiotensin II type 1 receptor, and angiotensin-converting enzyme. 6β-Hydroxytestosterone did not alter angiotensin II-induced renal fibrosis, inflammation, oxidative stress, urinary excretion of angiotensinogen, expression of angiotensin II type 1 receptor, or angiotensin-converting enzyme in Cyp1b1(+/+)mice. However, in Cyp1b1(-/-) or castrated Cyp1b1(+/+) mice, it restored these effects of angiotensin II. These data indicate that 6β-hydroxytestosterone contributes to increased thirst, impairment of renal function, and end-organ injury associated with angiotensin II-induced hypertension in male mice and that cytochrome P450 1B1 could serve as a novel target for treating renal disease and hypertension in male mice."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.org/dc/terms/identifier | "doi:10.1161/hypertensionaha.115.06936"xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/author | "Kara M."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/author | "Gonzalez F.J."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/author | "Brand D.D."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/author | "Navar L.G."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/author | "Thirunavukkarasu S."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/author | "Katsurada A."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/author | "Malik K.U."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/author | "Majid D.S."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/author | "Pingili A.K."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/pages | "916-926"xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/title | "6beta-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice."xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/26928804 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26928804 |
| http://purl.uniprot.org/citations/26928804 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26928804 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-26928804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26928804 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4L2V1-mappedCitation-26928804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26928804 |
| http://purl.uniprot.org/uniprot/#_F6Z9G5-mappedCitation-26928804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26928804 |
| http://purl.uniprot.org/uniprot/#_P25799-mappedCitation-26928804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26928804 |
| http://purl.uniprot.org/uniprot/#_Q64429-mappedCitation-26928804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26928804 |
| http://purl.uniprot.org/uniprot/#_Q3UTK2-mappedCitation-26928804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26928804 |