| http://purl.uniprot.org/citations/26929214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26929214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26929214 | http://www.w3.org/2000/01/rdf-schema#comment | "The Katanin family of microtubule-severing enzymes is critical for remodeling microtubule-based structures that influence cell division, motility, morphogenesis and signaling. Katanin is composed of a catalytic p60 subunit (A subunit, KATNA1) and a regulatory p80 subunit (B subunit, KATNB1). The mammalian genome also encodes two additional A-like subunits (KATNAL1 and KATNAL2) and one additional B-like subunit (KATNBL1) that have remained poorly characterized. To better understand the factors and mechanisms controlling mammalian microtubule-severing, we have taken a mass proteomic approach to define the protein interaction module for each mammalian Katanin subunit and to generate the mammalian Katanin family interaction network (Katan-ome). Further, we have analyzed the function of the KATNBL1 subunit and determined that it associates with KATNA1 and KATNAL1, it localizes to the spindle poles only during mitosis and it regulates Katanin A subunit microtubule-severing activity in vitro Interestingly, during interphase, KATNBL1 is sequestered in the nucleus through an N-terminal nuclear localization signal. Finally KATNB1 was able to compete the interaction of KATNBL1 with KATNA1 and KATNAL1. These data indicate that KATNBL1 functions as a regulator of Katanin A subunit microtubule-severing activity during mitosis and that it likely coordinates with KATNB1 to perform this function."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m115.056465"xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m115.056465"xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Cheung K."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Cheung K."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Whitelegge J.P."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Whitelegge J.P."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Kuang J."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Kuang J."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Ongpipattanakul C."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Ongpipattanakul C."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Cohn W."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Cohn W."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Torres J.Z."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Torres J.Z."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Bui N."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Bui N."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Capri J."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Capri J."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Gholkar A."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Gholkar A."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Senese S."xsd:string |
| http://purl.uniprot.org/citations/26929214 | http://purl.uniprot.org/core/author | "Senese S."xsd:string |