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http://purl.uniprot.org/citations/26932430http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26932430http://www.w3.org/2000/01/rdf-schema#comment"

Background

To evaluate the expression of beta-catenin (β-catenin) and SKP2 proteins in superficial bladder cancer cases and their correlation with tumor grade and stage.

Methods

After institutional review board approval, we retrospectively evaluated the expression of β-catenin and SKP2 proteins in tissue specimens from patients with non-muscle invasive bladder cancer (NMIBC) and compared their results with a cohort of chronic nonspecific cystitis's. Then we and explored these markers association with tumor grade and stage.

Results

A total of 40 patients were retrospectively identified, 50% was NMIBC and the rest were chronic nonspecific cystitis. β-catenin was expressed in 18 (90%) patients of the NMIBC group in comparison to 14 (70%) of the control group with (P=0.1), while SKP2 protein was only expressed in NMIBC groups (P=0.03). A statistically significant correlation was identified between nucleocytoplasmic localization of β-catenin and SKP2 with tumor grade, stage.

Conclusions

β-catenin and SKP2 expression are providing promising results for differentiating higher grade and stage non muscle invasive bladder cancers."xsd:string
http://purl.uniprot.org/citations/26932430http://purl.org/dc/terms/identifier"doi:10.3978/j.issn.2304-3865.2016.02.02"xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/author"Dawood M."xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/author"Gaber M.A."xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/author"Elkady N."xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/author"Badawy A."xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/author"Elbaky T.A."xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/author"Elserafy F."xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/author"Elsherif E."xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/author"Gharabawy M.E."xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/name"Chin Clin Oncol"xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/pages"6"xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/title"beta-catenin and SKP2 proteins as predictors of grade and stage of non-muscle invasive urothelial bladder carcinoma."xsd:string
http://purl.uniprot.org/citations/26932430http://purl.uniprot.org/core/volume"5"xsd:string
http://purl.uniprot.org/citations/26932430http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26932430
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