| http://purl.uniprot.org/citations/26932439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26932439 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of AMPA receptor (AMPAR)-mediated synaptic transmission is a key mechanism for synaptic plasticity. In the brain, AMPARs assemble with a number of auxiliary subunits, including TARPs, CNIHs and CKAMP44, which are important for AMPAR forward trafficking to synapses. Here we report that the membrane protein GSG1L negatively regulates AMPAR-mediated synaptic transmission. Overexpression of GSG1L strongly suppresses, and GSG1L knockout (KO) enhances, AMPAR-mediated synaptic transmission. GSG1L-dependent regulation of AMPAR synaptic transmission relies on the first extracellular loop domain and its carboxyl-terminus. GSG1L also speeds up AMPAR deactivation and desensitization in hippocampal CA1 neurons, in contrast to the effects of TARPs and CNIHs. Furthermore, GSG1L association with AMPARs inhibits CNIH2-induced slowing of the receptors in heterologous cells. Finally, GSG1L KO rats have deficits in LTP and show behavioural abnormalities in object recognition tests. These data demonstrate that GSG1L represents a new class of auxiliary subunit with distinct functional properties for AMPARs."xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms10873"xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/author | "Mao X."xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/author | "Gu X."xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/author | "Roche K.W."xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/author | "Hamra F.K."xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/author | "Lussier M.P."xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/author | "Hutchison M.A."xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/pages | "10873"xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/title | "GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons."xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26932439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26932439 |
| http://purl.uniprot.org/citations/26932439 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26932439 |
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| http://purl.uniprot.org/uniprot/#_D3Z7H4-mappedCitation-26932439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26932439 |
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| http://purl.uniprot.org/uniprot/#_A6I929-mappedCitation-26932439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26932439 |
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| http://purl.uniprot.org/uniprot/#_B0QZW1-mappedCitation-26932439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26932439 |