| http://purl.uniprot.org/citations/26940223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26940223 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we show that cancer stem cells amount in human lung adenocarcinoma cell line A549 depends on E-cadherin expression. In fact, downregulation of E-cadherin expression enhanced expression of pluripotent genes (c-MYC, NESTIN, OCT3/4 and SOX2) and enriched cell population with the cells possessing the properties of so-called 'cancer stem cells' via activation of Wnt/β-catenin signaling. Repression of E-cadherin also stimulated cell proliferation and migration in vitro, decreased cell amount essential for xenografts formation in nude mice, increased tumors vascularization and growth. On the other hand, E-cadherin upregulation caused opposite effects i.e. diminished the number of cancer stem cells, decreased xenograft vascularization and decelerated tumor growth. Therefore, agents restoring E-cadherin expression may be useful in anticancer therapy."xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.org/dc/terms/identifier | "doi:10.1080/15384101.2016.1156268"xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/author | "Dugina V."xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/author | "Khromova N."xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/author | "Kopnin P."xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/author | "Rybko V."xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/author | "Farmakovskaya M."xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/author | "Kopnin B."xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/pages | "1084-1092"xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/title | "E-Cadherin repression increases amount of cancer stem cells in human A549 lung adenocarcinoma and stimulates tumor growth."xsd:string |
| http://purl.uniprot.org/citations/26940223 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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