| http://purl.uniprot.org/citations/26943323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26943323 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear factor kappa B (NF-κB) promotes cell survival in response to genotoxic stress by inducing the expression of anti-apoptotic proteins including Bcl-xL, which protects mitochondria from stress-induced mitochondrial outer membrane permeabilization (MOMP). Here we show that the multifunctional sorting protein Pacs-2 (phosphofurin acidic cluster sorting protein-2) is required for Bcl-xL induction following DNA damage in primary mouse thymocytes. Consequently, in response to DNA damage, Pacs-2(-/-) thymocytes exhibit a blunted induction of Bcl-xL, increased MOMP and accelerated apoptosis. Biochemical studies show that cytoplasmic PACS-2 promotes this DNA damage-induced anti-apoptotic pathway by interacting with ataxia telangiectasia mutated (ATM) to drive NF-κB activation and induction of Bcl-xL. However, Pacs-2 was not required for tumor necrosis factor-α-induced NF-κB activation, suggesting a role for PACS-2 selectively in NF-κB activation in response to DNA damage. These findings identify PACS-2 as an in vivo mediator of the ATM and NF-κB-dependent induction of Bcl-xL that promotes cell survival in response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2016.23"xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/author | "Thomas L."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/author | "Luan S."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/author | "Atkins K.M."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/author | "Thomas L.L."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/author | "Barroso-Gonzalez J."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/author | "Aslan J.E."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/author | "Auclair S."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/pages | "1448-1457"xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/title | "PACS-2 mediates the ATM and NF-kappaB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/26943323 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26943323 |
| http://purl.uniprot.org/citations/26943323 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26943323 |
| http://purl.uniprot.org/uniprot/#_E9Q7E9-mappedCitation-26943323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26943323 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VLZ7-mappedCitation-26943323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26943323 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VN58-mappedCitation-26943323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26943323 |
| http://purl.uniprot.org/uniprot/#_Q3V3Q7-mappedCitation-26943323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26943323 |
| http://purl.uniprot.org/uniprot/#_Q3V3Y3-mappedCitation-26943323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26943323 |