| http://purl.uniprot.org/citations/26949251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26949251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26949251 | http://www.w3.org/2000/01/rdf-schema#comment | "Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls heterochromatin organisation. Altering Ki-67 expression levels did not significantly affect cell proliferation in vivo. Ki-67 mutant mice developed normally and cells lacking Ki-67 proliferated efficiently. Conversely, upregulation of Ki-67 expression in differentiated tissues did not prevent cell cycle arrest. Ki-67 interactors included proteins involved in nucleolar processes and chromatin regulators. Ki-67 depletion disrupted nucleologenesis but did not inhibit pre-rRNA processing. In contrast, it altered gene expression. Ki-67 silencing also had wide-ranging effects on chromatin organisation, disrupting heterochromatin compaction and long-range genomic interactions. Trimethylation of histone H3K9 and H4K20 was relocalised within the nucleus. Finally, overexpression of human or Xenopus Ki-67 induced ectopic heterochromatin formation. Altogether, our results suggest that Ki-67 expression in proliferating cells spatially organises heterochromatin, thereby controlling gene expression."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.13722"xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.13722"xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Feil R."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Feil R."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Camasses A."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Camasses A."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Urbach S."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Urbach S."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Hem S."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Hem S."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Nicolas E."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Nicolas E."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "David A."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "David A."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Fisher D."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Fisher D."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Malumbres M."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Malumbres M."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Jay P."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Jay P."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Lafontaine D.L.J."xsd:string |
| http://purl.uniprot.org/citations/26949251 | http://purl.uniprot.org/core/author | "Lafontaine D.L.J."xsd:string |