| http://purl.uniprot.org/citations/26952936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26952936 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromatin structure is determined by nucleosome positioning, histone modifications, and DNA methylation. How chromatin modifications are coordinately altered under pathological conditions remains elusive. Here we describe a stress-activated mechanism of concerted chromatin modification in the heart. In mice, pathological stress activates cardiomyocytes to express Brg1 (nucleosome-remodeling factor), G9a/Glp (histone methyltransferase), and Dnmt3 (DNA methyltransferase). Once activated, Brg1 recruits G9a and then Dnmt3 to sequentially assemble repressive chromatin-marked by H3K9 and CpG methylation-on a key molecular motor gene (Myh6), thereby silencing Myh6 and impairing cardiac contraction. Disruption of Brg1, G9a or Dnmt3 erases repressive chromatin marks and de-represses Myh6, reducing stress-induced cardiac dysfunction. In human hypertrophic hearts, BRG1-G9a/GLP-DNMT3 complex is also activated; its level correlates with H3K9/CpG methylation, Myh6 repression, and cardiomyopathy. Our studies demonstrate a new mechanism of chromatin assembly in stressed hearts and novel therapeutic targets for restoring Myh6 and ventricular function. The stress-induced Brg1-G9a-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2016.03.002"xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Han P."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Lin C.H."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Zhao M."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Wong J."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Li D.Y."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Bernstein D."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Cheng W."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Shang C."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Chen H.S."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Quertermous T."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Ghetti A."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Chang C.P."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Cheng H.L."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Hang C.T."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/author | "Drakos S.G."xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/26952936 | http://purl.uniprot.org/core/pages | "1772-1781"xsd:string |