| http://purl.uniprot.org/citations/26952977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26952977 | http://www.w3.org/2000/01/rdf-schema#comment | "In the epidermis of mice lacking transcription factor nuclear factor-kappa B (NF-κB) activity, primary hair follicle (HF) pre-placode formation is initiated without progression to proper placodes. NF-κB modulates WNT and SHH signaling at early stages of HF development, but this does not fully account for the phenotypes observed upon NF-κB inhibition. To identify additional NF-κB target genes, we developed a novel method to isolate and transcriptionally profile primary HF placodes with active NF-κB signaling. In parallel, we compared gene expression at the same developmental stage in NF-κB-deficient embryos and controls. This uncovered novel NF-κB target genes with potential roles in priming HF placodes for down-growth. Importantly, we identify Lhx2 (encoding a LIM/homeobox transcription factor) as a direct NF-κB target gene, loss of which replicates a subset of phenotypes seen in NF-κB-deficient embryos. Lhx2 and Tgfb2 knockout embryos exhibit very similar abnormalities in HF development, including failure of the E-cadherin suppression required for follicle down-growth. We show that TGFβ2 signaling is impaired in NF-κB-deficient and Lhx2 knockout embryos and that exogenous TGFβ2 rescues the HF phenotypes in Lhx2 knockout skin explants, indicating that it operates downstream of LHX2. These findings identify a novel NF-κB/LHX2/TGFβ2 signaling axis that is crucial for primary HF morphogenesis, which may also function more broadly in development and disease."xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.130898"xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://purl.uniprot.org/core/author | "Schmidt-Ullrich R."xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://purl.uniprot.org/core/author | "Paus R."xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://purl.uniprot.org/core/author | "Millar S.E."xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://purl.uniprot.org/core/author | "Scheidereit C."xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://purl.uniprot.org/core/author | "Tomann P."xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26952977 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://purl.uniprot.org/core/pages | "1512-1522"xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://purl.uniprot.org/core/title | "Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth."xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://purl.uniprot.org/core/volume | "143"xsd:string |
| http://purl.uniprot.org/citations/26952977 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26952977 |
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