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http://purl.uniprot.org/citations/26954704http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26954704http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Behçet disease (BD) is predominantly found between East Asia and the Mediterranean basin along the historic Silk Road. HLA-B51 is known to be strongly associated with BD. We investigated the association between HLA-B51 and the ocular manifestations of BD among various ethnic groups.

Methods

A literature survey was conducted, and 18 articles written in English were reviewed.

Results

A strong correlation was found between HLA-B51 and ocular lesions in the entire cohort discussed in the reviewed articles (OR = 1.76, p = 0.000057). HLA-B51 was shown to have a strong association with ocular manifestations of BD patients in East-Eurasian (OR = 2.40, p = 0.0030) and Middle-Eurasian (OR = 1.87, p = 0.0045), but not in West-Eurasian (OR = 1.28, p = 0.35) areas. This correlation seemed to become stronger towards the east.

Conclusions

A meta-analysis showed that the correlation became stronger towards the east along the Silk Road. The study results may facilitate understanding of the etiology and characteristics of BD."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.org/dc/terms/identifier"doi:10.3109/09273948.2015.1136422"xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Ishida S."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Inoko H."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Namba K."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Ohta T."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Ohno S."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Ota M."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Mizuuchi K."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Horie Y."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Mizuki N."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Meguro A."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Iwata D."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Kitaichi N."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/author"Lee E.B."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/name"Ocul Immunol Inflamm"xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/pages"37-40"xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/title"HLA-B51 Carriers are Susceptible to Ocular Symptoms of Behcet Disease and the Association between the Two Becomes Stronger towards the East along the Silk Road: A Literature Survey."xsd:string
http://purl.uniprot.org/citations/26954704http://purl.uniprot.org/core/volume"25"xsd:string
http://purl.uniprot.org/citations/26954704http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26954704
http://purl.uniprot.org/citations/26954704http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26954704
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-26954704http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26954704
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-26954704http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26954704
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