| http://purl.uniprot.org/citations/26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26961947 | http://www.w3.org/2000/01/rdf-schema#comment | "In vertebrate retina, light responses generated by the rod photoreceptors are transmitted to the second-order neurons, the ON-bipolar cells (ON-BC), and this communication is indispensible for vision in dim light. In ON-BCs, synaptic transmission is initiated by the metabotropic glutamate receptor, mGluR6, that signals via the G-protein Go to control opening of the effector ion channel, TRPM1. A key role in this process belongs to the GTPase Activating Protein (GAP) complex that catalyzes Go inactivation upon light-induced suppression of glutamate release in rod photoreceptors, thereby driving ON-BC depolarization to changes in synaptic input. The GAP complex has a striking molecular complexity. It contains two Regulator of G-protein Signaling (RGS) proteins RGS7 and RGS11 that directly act on Go and two adaptor subunits: RGS Anchor Protein (R9AP) and the orphan receptor, GPR179. Here we examined the organizational principles of the GAP complex in ON-BCs. Biochemical experiments revealed that RGS7 binds to a conserved site in GPR179 and that RGS11 in vivo forms a complex only with R9AP. R9AP and GPR179 are further integrated via direct protein-protein interactions involving their cytoplasmic domains. Elimination of GPR179 prevents postsynaptic accumulation of R9AP. Furthermore, concurrent knock-out of both R9AP and RGS7 does not reconfigure the GAP complex and completely abolishes synaptic transmission, resulting in a novel mouse model of night blindness. Based on these results, we propose a model of hierarchical assembly and function of the GAP complex that supports ON-BCs visual signaling."xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3833-15.2016"xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://purl.uniprot.org/core/author | "Gregg R.G."xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://purl.uniprot.org/core/author | "Martemyanov K.A."xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://purl.uniprot.org/core/author | "Orlandi C."xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://purl.uniprot.org/core/author | "McCall M.A."xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://purl.uniprot.org/core/author | "Sarria I."xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26961947 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://purl.uniprot.org/core/pages | "2915-2925"xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://purl.uniprot.org/core/title | "Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons."xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/26961947 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26961947 |
| http://purl.uniprot.org/citations/26961947 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26961947 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVV6-mappedCitation-26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26961947 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW36-mappedCitation-26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26961947 |
| http://purl.uniprot.org/uniprot/#_E9QNN3-mappedCitation-26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26961947 |
| http://purl.uniprot.org/uniprot/#_E9PY61-mappedCitation-26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26961947 |
| http://purl.uniprot.org/uniprot/#_G3X8W6-mappedCitation-26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26961947 |
| http://purl.uniprot.org/uniprot/#_O54829-mappedCitation-26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26961947 |
| http://purl.uniprot.org/uniprot/#_Q8BFV4-mappedCitation-26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26961947 |
| http://purl.uniprot.org/uniprot/#_Q148R9-mappedCitation-26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26961947 |
| http://purl.uniprot.org/uniprot/#_Q45FE1-mappedCitation-26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26961947 |
| http://purl.uniprot.org/uniprot/#_Q45FE2-mappedCitation-26961947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26961947 |