| http://purl.uniprot.org/citations/26964537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26964537 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundGrand-glass nodule for CT image has thought to be less aggressive tumor in lung cancer. Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK)-positive lung cancer presenting with Ground-glass nodules (GGNs) is relatively rare, and few such cases have been reported.Case presentationAn asymptomatic 56-year-old woman exhibited a 1.1-cm GGN in the lower lobe of the left lung on computed tomography during a medical checkup. Positron emission tomography showed no difference in uptake by the nodule compared with other organs. We elected to perform surgery because the nodule included a solid component and had grown only slightly during the last 2 years according to thin-section computed tomography. Partial resection of the lower left lung was performed by video-assisted thoracic surgery. Pathological examination revealed mucus-producing high columnar epithelium forming an irregular tubular-acinar-like structure partly replacing the alveolar epithelium on hematoxylin and eosin staining. More than 50 % of the tumor demonstrated a lepidic growth pattern. The tumor was negative for epidermal growth factor receptor mutation but positive for the EML4-ALK fusion oncogene according to fluorescence in situ hybridization.ConclusionsWe herein report a case of EML4-ALK-positive lung cancer presenting with a GGN along with a review of the relevant literature, including histopathological findings and imaging features. We consider that EML4-ALK-positive lung cancer is often highly progressive and that careful follow-up is therefore essential in these patients."xsd:string |
| http://purl.uniprot.org/citations/26964537 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12957-016-0841-5"xsd:string |
| http://purl.uniprot.org/citations/26964537 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/26964537 | http://purl.uniprot.org/core/author | "Higuchi M."xsd:string |
| http://purl.uniprot.org/citations/26964537 | http://purl.uniprot.org/core/author | "Owada Y."xsd:string |
| http://purl.uniprot.org/citations/26964537 | http://purl.uniprot.org/core/author | "Yonechi A."xsd:string |
| http://purl.uniprot.org/citations/26964537 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26964537 | http://purl.uniprot.org/core/name | "World J Surg Oncol"xsd:string |
| http://purl.uniprot.org/citations/26964537 | http://purl.uniprot.org/core/pages | "81"xsd:string |
| http://purl.uniprot.org/citations/26964537 | http://purl.uniprot.org/core/title | "Ground-glass nodule in a patient with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK)-positive lung cancer: a case report."xsd:string |
| http://purl.uniprot.org/citations/26964537 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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