| http://purl.uniprot.org/citations/26965284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26965284 | http://www.w3.org/2000/01/rdf-schema#comment | "Missing in metastasis (MIM) is abundantly expressed in hematopoietic cells. Here we characterized the impact of MIM deficiency on murine bone marrow (BM) cells. Although MIM(-/-) cells proliferated similarly to wild type (WT), they exhibited stronger response to chemokine stromal-derived factor 1 (SDF-1), increase in surface expression of CXCR4, impaired CXCR4 internalization and constitutive activation of Rac, Cdc42 and p38. Transplantation of MIM(-/-) BM cells into lethally irradiated mice showed enhanced homing to BM, which was abolished when mice were pretreated with a p38 antagonist. Interestingly, MIM(-/-) BM cells, including hematopoietic stem and progenitor cells (HSPCs), showed two-to fivefold increase in mobilization into the peripheral blood upon treatment with AMD3100. In vitro, MIM(-/-) leukocytes were susceptible to AMD3100 and maintained increased response to AMD3100 for mobilization even after transfer into WT mice. MIM(-/-) mice had also a higher level of SDF-1 in the circulation. Our data highlighted an unprecedented role of MIM in the homeostasis of BM cells, including HSPCs, through modulation of the CXCR4/SDF-1 axis and interactions of BM leukocytes with their microenvironments."xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.org/dc/terms/identifier | "doi:10.1038/leu.2016.39"xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/author | "Cao C."xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/author | "Zhan X."xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/author | "Civin C.I."xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/author | "Gu N."xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/author | "Zhan T."xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/pages | "1327-1334"xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/title | "MIM regulates the trafficking of bone marrow cells via modulating surface expression of CXCR4."xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/26965284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26965284 |
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| http://purl.uniprot.org/uniprot/#_P70658-mappedCitation-26965284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26965284 |
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| http://purl.uniprot.org/uniprot/#_A1E2I3-mappedCitation-26965284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26965284 |
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