| http://purl.uniprot.org/citations/26965643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26965643 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia, a feature common to most solid tumors, is known to regulate many aspects of tumorigenesis. Recently, it was suggested that hypoxia increased the size of the cancer stem-cell (CSC) subpopulations and promoted the acquisition of a CSC-like phenotype. However, candidate hypoxia-regulated mediators specifically relevant to the stemness-related functions of colorectal CSCs have not been examined in detail. In the present study, we showed that hypoxia specifically promoted the self-renewal potential of CSCs. Through various in vitro studies, we found that hypoxia-induced Wnt/β-catenin signaling increased the occurrence of CSC-like phenotypes and the level of Id2 expression in colorectal-cancer cells. Importantly, the levels of hypoxia-induced CSC-sphere formation and Id2 expression were successfully attenuated by treatment with a Wnt/β-catenin-signaling inhibitor. We further demonstrated, for the first time, that the degree of hypoxia-induced CSC-sphere formation (CD44(+) subpopulation) in vitro and of tumor metastasis/dissemination in vivo were markedly suppressed by knocking down Id2 expression. Taken together, these data suggested that Wnt/β-catenin signaling mediated the hypoxia-induced self-renewal potential of colorectal-cancer CSCs through reactivating Id2 expression."xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep22966"xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/author | "Lee H.Y."xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/author | "Kim J.Y."xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/author | "Nam J.S."xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/author | "Park S.R."xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/author | "Dong H.J."xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/author | "Hong I.S."xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/author | "Jang G.B."xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/pages | "22966"xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/title | "The Wnt/beta-catenin signaling/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells."xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26965643 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26965643 |
| http://purl.uniprot.org/citations/26965643 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26965643 |
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