| http://purl.uniprot.org/citations/26966907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26966907 | http://www.w3.org/2000/01/rdf-schema#comment | "Gastric mucosa-associated lymphoid tissue (MALT) lymphomas develop from a chronic Helicobacter infection. Phospholipase C gamma 2 (PLCG2) is important for B-cell survival and proliferation. We used BALB/c mice with a gain-of-function mutation in the Plcg2 gene (Ali5) to analyze its role in the development of gastric MALT lymphoma. Heterozygous BALB/c Plcg2Ali5/+ and wildtype (WT) mice were infected with Helicobacter felis (H. felis) and observed up to 16 months for development of gastric MALT lymphomas. In contrast to our initial hypothesis, Plcg2Ali5/+ mice developed MALT lymphomas less frequently than their WT littermates after long-term infection of 16 months. Infected Plcg2Ali5/+ mice showed downregulation of proinflammatory cytokines and decreased H. felis-specific IgG1 and IgG2a antibody responses. These results suggested a blunted immune response of Plcg2Ali5/+ mice towards H. felis infection. Intriguingly, Plcg2Ali5/+ mice harboured higher numbers of CD73 expressing regulatory T cells (Tregs), possibly responsible for impaired immune response towards Helicobacter infection. We suggest that Plcg2Ali5/+ mice may be protected from developing gastric MALT lymphomas as a result of elevated Treg numbers, reduced response to H. felis and decrease of proinflammatory cytokines."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0150411"xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Moll R."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Yu P."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Neubauer A."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Brendel C."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Stolte M."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Finkernagel F."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Lohoff M."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Garn H."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Gossmann J."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Bittner A."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/author | "Huynh M.Q."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/pages | "e0150411"xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/title | "A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma."xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/26966907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26966907 |
| http://purl.uniprot.org/citations/26966907 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26966907 |
| http://purl.uniprot.org/uniprot/#_Q8CIH5-mappedCitation-26966907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26966907 |
| http://purl.uniprot.org/uniprot/Q8CIH5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26966907 |