| http://purl.uniprot.org/citations/26972460 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26972460 | http://www.w3.org/2000/01/rdf-schema#comment | "The LC8 family of small ~8 kD proteins are highly conserved and interact with multiple protein partners in eukaryotic cells. LC8-binding modulates target protein activity, often through induced dimerization via LC8:LC8 homodimers. Although many LC8-interactors have roles in signaling cascades, LC8's role in developing epithelia is poorly understood. Using the Drosophila wing as a developmental model, we find that the LC8 family member Cut up (Ctp) is primarily required to promote epithelial growth, which correlates with effects on the pro-growth factor dMyc and two genes, diap1 and bantam, that are classic targets of the Hippo pathway coactivator Yorkie. Genetic tests confirm that Ctp supports Yorkie-driven tissue overgrowth and indicate that Ctp acts through Yorkie to control bantam (ban) and diap1 transcription. Quite unexpectedly however, Ctp loss has inverse effects on ban and diap1: it elevates ban expression but reduces diap1 expression. In both cases these transcriptional changes map to small segments of these promoters that recruit Yorkie. Although LC8 complexes with Yap1, a Yorkie homolog, in human cells, an orthologous interaction was not detected in Drosophila cells. Collectively these findings reveal that that Drosophila Ctp is a required regulator of Yorkie-target genes in vivo and suggest that Ctp may interact with a Hippo pathway protein(s) to exert inverse transcriptional effects on Yorkie-target genes."xsd:string |
| http://purl.uniprot.org/citations/26972460 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep22726"xsd:string |
| http://purl.uniprot.org/citations/26972460 | http://purl.uniprot.org/core/author | "Moberg K."xsd:string |
| http://purl.uniprot.org/citations/26972460 | http://purl.uniprot.org/core/author | "Barron D.A."xsd:string |
| http://purl.uniprot.org/citations/26972460 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26972460 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/26972460 | http://purl.uniprot.org/core/pages | "22726"xsd:string |
| http://purl.uniprot.org/citations/26972460 | http://purl.uniprot.org/core/title | "Inverse regulation of two classic Hippo pathway target genes in Drosophila by the dimerization hub protein Ctp."xsd:string |
| http://purl.uniprot.org/citations/26972460 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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