| http://purl.uniprot.org/citations/26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26977885 | http://www.w3.org/2000/01/rdf-schema#comment | "We report that the protein kinase Cι (PKCι) oncogene controls expression of NOTCH3, a key driver of stemness, in KRAS-mediated lung adenocarcinoma (LADC). PKCι activates NOTCH3 expression by phosphorylating the ELF3 transcription factor and driving ELF3 occupancy on the NOTCH3 promoter. PKCι-ELF3-NOTCH3 signaling controls the tumor-initiating cell phenotype by regulating asymmetric cell division, a process necessary for tumor initiation and maintenance. Primary LADC tumors exhibit PKCι-ELF3-NOTCH3 signaling, and combined pharmacologic blockade of PKCι and NOTCH synergistically inhibits tumorigenic behavior in vitro and LADC growth in vivo demonstrating the therapeutic potential of PKCι-ELF3-NOTCH3 signal inhibition to more effectively treat KRAS LADC."xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2016.02.012"xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://purl.uniprot.org/core/author | "Ali S.A."xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://purl.uniprot.org/core/author | "Jamieson L."xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://purl.uniprot.org/core/author | "Fields A.P."xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://purl.uniprot.org/core/author | "Justilien V."xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://purl.uniprot.org/core/author | "Murray N.R."xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26977885 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://purl.uniprot.org/core/pages | "367-378"xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://purl.uniprot.org/core/title | "Protein Kinase Ciota Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma."xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/26977885 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26977885 |
| http://purl.uniprot.org/citations/26977885 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26977885 |
| http://purl.uniprot.org/uniprot/#_A0A221ZRZ1-mappedCitation-26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26977885 |
| http://purl.uniprot.org/uniprot/#_A0A5P8I3H7-mappedCitation-26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26977885 |
| http://purl.uniprot.org/uniprot/#_A0A221ZRZ4-mappedCitation-26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26977885 |
| http://purl.uniprot.org/uniprot/#_A0A221ZRZ5-mappedCitation-26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26977885 |
| http://purl.uniprot.org/uniprot/#_A5HC25-mappedCitation-26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26977885 |
| http://purl.uniprot.org/uniprot/#_A5HC02-mappedCitation-26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26977885 |
| http://purl.uniprot.org/uniprot/#_A5HC19-mappedCitation-26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26977885 |
| http://purl.uniprot.org/uniprot/#_A5HC23-mappedCitation-26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26977885 |
| http://purl.uniprot.org/uniprot/#_P78545-mappedCitation-26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26977885 |
| http://purl.uniprot.org/uniprot/#_E5FF39-mappedCitation-26977885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26977885 |