| http://purl.uniprot.org/citations/26979752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26979752 | http://www.w3.org/2000/01/rdf-schema#comment | "HLA-A is a locus of the major histocompatibility complex situated on chromosome 6p21.3. HLA-A has been shown to be associated with susceptibility to Alzheimer's disease (AD). In this study, we firstly investigated the association of gene variants in HLA-A and brain structures on MRI in a large sample from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to explore the effects of HLA-A on AD pathogenesis. We selected the hippocampus, parahippocampus, posterior cingulate, precuneus, middle temporal, entorhinal cortex, and amygdala as regions of interest (ROIs). In hybrid population analysis, our results showed a marginally significant association between rs9260168 and the atrophy of the left parahippocampus (P = 0.007, Pc = 0.054), rs3823342 and the atrophy of the left parahippocampus (P = 0.014, Pc = 0.054), rs76475517, which only exists in Caucasians with HLA-A23 or HLA-A24 alleles, and the atrophy of the right amygdala (P = 0.010, Pc = 0.085) at baseline. In particular, the haplotype (TGACAAGG), as a surrogate marker of HLA-A2, was founded to be positively associated with the atrophy of the right hippocampus (P = 0.047) at baseline. Furthermore, we detected the above four associations in mild cognitive impairment (MCI) subpopulation analysis. Our study provided preliminary evidences supporting HLA-A2 in Caucasians contribute to the risk of AD by modulating the alteration of hippocampal volume and HLA-A gene variants appear to play a role in altering AD-related brain structures on MRI."xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12035-016-9832-3"xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/author | "Jiang T."xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/author | "Wang H.F."xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/author | "Tan L."xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/author | "Wang Z.X."xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/author | "Tan C.C."xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/author | "Tan M.S."xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/author | "Yu J.T."xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/author | "Tan L.'"xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/author | "Sun F.R."xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/name | "Mol Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/pages | "2469-2476"xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/title | "HLA-A2 Alleles Mediate Alzheimer's Disease by Altering Hippocampal Volume."xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/26979752 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26979752 |
| http://purl.uniprot.org/citations/26979752 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26979752 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-26979752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26979752 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-26979752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26979752 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-26979752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26979752 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-26979752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26979752 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-26979752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26979752 |
| http://purl.uniprot.org/uniprot/#_A0A076JXB7-mappedCitation-26979752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26979752 |