| http://purl.uniprot.org/citations/26980051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26980051 | http://www.w3.org/2000/01/rdf-schema#comment | "The effects of oxidative stress in adenocarcinomas of gastric cardia (AGCs) have not been fully elucidated. With a strict definition of AGC, we examined the immunohistochemical expressions of inducible nitric oxide synthase; 8-hydroxy-deoxyguanosine; and the base excision repair enzymes such as MUTYH, MTH1, and OGG1, and TP53 mutational status. Sixty-three cases of AGC were characterized by younger patient age (P = .0227) and more frequent venous invasion (P = .0106) compared with the adenocarcinomas of pylorus (APs). 8-hydroxy-deoxyguanosine was accumulated (P = .0011), whereas MUTYH (P = .0325) and OGG1 (P = .0007) were decreased, in the AGCs compared with the adjacent mucosa, but these differences were not detected in the APs. Among the AGCs, lower expressions of MUTYH (P = .0013) and MTH1 (P = .0059) were each significantly associated with diffuse-type histology. A lower expression of OGG1 was correlated with higher T-stage (P = .0011), lymphatic invasion (P = .004), and lymph node metastasis (P = .0094). In addition, the presence of TP53 mutation was associated with diffuse-type histology (P = .0153) and a lower level of MUTYH (P = .0221). The AGCs also showed a relatively high rate of a transversion-type mutation of TP53 (50%), whereas all TP53 mutations in the APs were transition type. Age 62years or older (P = .0073), diffuse-type histology (P = .0020), and TP53 mutation (P = .0066) were each associated with worse survival in the AGC patients. Our results indicate that oxidative stress accumulation and a downregulation of base excision repair enzymes may play an important role in the pathogenesis of AGC, in particular diffuse-type AGCs. Diffuse-type AGC might involve molecular pathways different from those of other subsets of gastric cancer."xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humpath.2016.01.006"xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/author | "Oda Y."xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/author | "Nakamura M."xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/author | "Kohno Y."xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/author | "Oki E."xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/author | "Hirahashi M."xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/author | "Kumagae Y."xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/name | "Hum Pathol"xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/pages | "145-152"xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/title | "Reduced MUTYH, MTH1, and OGG1 expression and TP53 mutation in diffuse-type adenocarcinoma of gastric cardia."xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/26980051 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26980051 |
| http://purl.uniprot.org/citations/26980051 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26980051 |
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| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-26980051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26980051 |
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| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-26980051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26980051 |