| http://purl.uniprot.org/citations/26980730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26980730 | http://www.w3.org/2000/01/rdf-schema#comment | "Intraflagellar transport (IFT) is essential for assembly and maintenance of cilia and flagella as well as ciliary motility and signaling. IFT is mediated by multisubunit complexes, including IFT-A, IFT-B, and the BBSome, in concert with kinesin and dynein motors. Under high salt conditions, purified IFT-B complex dissociates into a core subcomplex composed of at least nine subunits and at least five peripherally associated proteins. Using the visible immunoprecipitation assay, which we recently developed as a convenient protein-protein interaction assay, we determined the overall architecture of the IFT-B complex, which can be divided into core and peripheral subcomplexes composed of 10 and 6 subunits, respectively. In particular, we identified TTC26/IFT56 and Cluap1/IFT38, neither of which was included with certainty in previous models of the IFT-B complex, as integral components of the core and peripheral subcomplexes, respectively. Consistent with this, a ciliogenesis defect of Cluap1-deficient mouse embryonic fibroblasts was rescued by exogenous expression of wild-type Cluap1 but not by mutant Cluap1 lacking the binding ability to other IFT-B components. The detailed interaction map as well as comparison of subcellular localization of IFT-B components between wild-type and Cluap1-deficient cells provides insights into the functional relevance of the architecture of the IFT-B complex."xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.713883"xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/author | "Katoh Y."xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/author | "Hamada H."xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/author | "Terada M."xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/author | "Nishijima Y."xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/author | "Takei R."xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/author | "Nozaki S."xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/pages | "10962-10975"xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/title | "Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex."xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/26980730 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26980730 |
| http://purl.uniprot.org/citations/26980730 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26980730 |
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