| http://purl.uniprot.org/citations/26982501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26982501 | http://www.w3.org/2000/01/rdf-schema#comment | "Ras guanine nucleotide-releasing protein-4 (RasGRP4) is an evolutionarily conserved calcium-regulated, guanine nucleotide exchange factor and diacylglycerol/phorbol ester receptor. While an important intracellular signaling protein for CD117+ mast cells (MCs), its roles in other immune cells is less clear. In this study, we identified a subset of in vivo-differentiated splenic CD117+ dendritic cells (DCs) in wild-type (WT) C57BL/6 mice that unexpectedly contained RasGRP4 mRNA and protein. In regard to the biologic significance of these data to innate immunity, LPS-treated splenic CD117+ DCs from WT mice induced natural killer (NK) cells to produce much more interferon-γ (IFN-γ) than comparable DCs from RasGRP4-null mice. The ability of LPS-responsive MCs to cause NK cells to increase their expression of IFN-γ was also dependent on this intracellular signaling protein. The discovery that RasGRP4 is required for CD117+ MCs and DCs to optimally induce acute NK cell-dependent immune responses to LPS helps explain why this signaling protein has been conserved in evolution."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0151638"xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Qi M."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Zhou S."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Krilis S.A."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "O'Keeffe M."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Stevens R.L."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Hamilton M.J."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Weaver J.C."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Giannakopoulos B."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Weatherall C."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "El-Assaad F."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/author | "Wensing L.A."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/pages | "e0151638"xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/title | "CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide."xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/26982501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26982501 |