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http://purl.uniprot.org/citations/26987266http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26987266http://www.w3.org/2000/01/rdf-schema#comment"

Background

Natriuretic peptides are diagnostic/prognostic biomarkers in major cardiovascular diseases. We aimed at assessing the predictive role of N-terminal pro-A-type (NT-proANP) and pro-B-type (NT-proBNP) natriuretic peptides levels toward cardiovascular outcome in both stable and unstable coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI) in a non-primary PCI setting.

Methods

A total of 395 patients undergoing PCI with stent implantation for either stable angina (SA) or non ST-elevation acute coronary syndrome (NSTE-ACS) were enrolled. Pre-procedural NT-proANP and NT-proBNP levels were measured. Occurrence of major adverse cardiac events (MACEs), composite of cardiac death, non-fatal myocardial infarction, and clinically driven target lesion revascularization (c-TLR), was the endpoint of the study. Follow up mean time was 48.53±14.69months.

Results

MACEs occurred in forty-four patients (11%) during follow up. Both NT-proANP levels [3170 (2210-4630) vs 2283 (1314-3913) fmol/mL, p=0.004] and NT-proBNP levels [729 (356-1353) vs 511 (267-1006) fmol/mL, p=0.04] were significantly higher in patients with MACEs compared to patients without MACEs. Similar results were found when considering hard MACEs (myocardial infarction and cardiac death). NT-proANP levels were significantly higher in patients with c-TLR compared with patients without c-TLR [3705 (2766-5184) vs 2343 (1340-3960) fmol/mL, p=0.021]. At multivariate analysis, NT-proANP levels were a significant predictor of MACEs (HR 1.09, 95% CI 1.03-1.18, p=0.04). Kaplan-Meyer curves revealed that patients with elevated NT-proANP levels (>2.100fmol/mL) had a lower MACE free survival (p=0.003).

Conclusions

Both NT-proANP and NT-proBNP levels were higher in CAD patients experiencing MACEs following PCI in a non-primary setting. Notably, only NT-proANP levels significantly affected prognosis after PCI."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.org/dc/terms/identifier"doi:10.1016/j.carrev.2016.02.012"xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Bianchi F."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Di Castro S."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Marchitti S."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Rubattu S."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Volpe M."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Conte M."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Roberto M."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Crea F."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Leone A.M."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Burzotta F."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Niccoli G."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Trani C."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Montone R.A."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Fracassi F."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/author"Grippo R."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/name"Cardiovasc Revasc Med"xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/pages"162-168"xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/title"NT-proANP and NT-proBNP circulating levels as predictors of cardiovascular outcome following coronary stent implantation."xsd:string
http://purl.uniprot.org/citations/26987266http://purl.uniprot.org/core/volume"17"xsd:string
http://purl.uniprot.org/citations/26987266http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26987266
http://purl.uniprot.org/citations/26987266http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26987266
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