| http://purl.uniprot.org/citations/26987684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26987684 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerical centrosome aberrations underlie certain developmental abnormalities and may promote cancer. A cell maintains normal centrosome numbers by coupling centrosome duplication with segregation, which is achieved through sustained association of each centrosome with a mitotic spindle pole. Although the microcephaly- and primordial dwarfism-linked centrosomal protein CEP215 has been implicated in this process, the molecular mechanism responsible remains unclear. Here, using proteomic profiling, we identify the minus end-directed microtubule motor protein HSET as a direct binding partner of CEP215. Targeted deletion of the HSET-binding domain of CEP215 in vertebrate cells causes centrosome detachment and results in HSET depletion at centrosomes, a phenotype also observed in CEP215-deficient patient-derived cells. Moreover, in cancer cells with centrosome amplification, the CEP215-HSET complex promotes the clustering of extra centrosomes into pseudo-bipolar spindles, thereby ensuring viable cell division. Therefore, stabilization of the centrosome-spindle pole interface by the CEP215-HSET complex could promote survival of cancer cells containing supernumerary centrosomes."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11005"xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/author | "Chavali P.L."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/author | "Chavali S."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/author | "Taylor C."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/author | "Gergely F."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/author | "Woods C.G."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/author | "Barr A.R."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/author | "Tatrai P."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/author | "Chandrasekaran G."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/author | "Papachristou E.K."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/pages | "11005"xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/title | "A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer."xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26987684 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26987684 |
| http://purl.uniprot.org/citations/26987684 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26987684 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MRG9-mappedCitation-26987684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26987684 |
| http://purl.uniprot.org/uniprot/#_A0A0C4ZLW1-mappedCitation-26987684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26987684 |
| http://purl.uniprot.org/uniprot/#_A0A024RCS7-mappedCitation-26987684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26987684 |
| http://purl.uniprot.org/uniprot/#_B3KVI2-mappedCitation-26987684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26987684 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X7X5-mappedCitation-26987684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26987684 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X7Y0-mappedCitation-26987684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26987684 |