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http://purl.uniprot.org/citations/26987707http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26987707http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The goal of this study was to investigate the relationship between polymorphisms in interleukin (IL)-12, IL-12R, IL-23, and IL-23R genes and Takayasu arteritis (TA) in a Chinese population.

Methods

A case-control study was performed to investigate the associations of 19 single nucleotide polymorphisms (SNPs) mapping to IL12A, IL12B, IL12RB1, IL12RB2 and IL23R with susceptibility to TA in 145 Chinese TA patients and 300 healthy controls. Genotype identification was performed with the MassARRAY system from Sequenom. The statistical analysis was conducted by Chi square test and unconditional logistic regression with plink.

Results

No significant differences were found for the distribution of allele and genotype frequencies of these SNPs between TA patients and healthy controls. However, a trend for IL12A rs582054 and IL23R rs1004819 in association with the TA phenotype was detected. TA patients carrying the rs582054/rs568408 haplotype (P' = 0.019) appeared less likely to progress to a more severe form of disease. And the C allele (P' = 0.082) of IL23R rs1004819 appeared to be a protective factor to refractory disease.

Conclusions

These findings suggest that the polymorphisms of IL12A, IL12B, IL12RB1, IL12RB2 and IL23R might make no contribution to the susceptibility of TA in the Chinese population."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.org/dc/terms/identifier"doi:10.1007/s00011-016-0938-x"xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Bian J."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Song L."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Wen D."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Meng X."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Zhang H.M."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Yang Y.K."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Zhou X.L."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Wu H.Y."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Wang L.P."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Yang K.Q."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/author"Jiang X.J."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/name"Inflamm Res"xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/pages"543-550"xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/title"Lack of association between polymorphisms in interleukin (IL)-12, IL-12R, IL-23, IL-23R genes and Takayasu arteritis in a Chinese population."xsd:string
http://purl.uniprot.org/citations/26987707http://purl.uniprot.org/core/volume"65"xsd:string
http://purl.uniprot.org/citations/26987707http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26987707
http://purl.uniprot.org/citations/26987707http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26987707
http://purl.uniprot.org/uniprot/#_D9N2T9-mappedCitation-26987707http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26987707
http://purl.uniprot.org/uniprot/#_A0A0C5PS98-mappedCitation-26987707http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26987707
http://purl.uniprot.org/uniprot/#_B6HY72-mappedCitation-26987707http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26987707
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